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    徠卡抗體Anaplastic Lymphoma Kinase
    產(chǎn)品型號：
    產(chǎn)品產(chǎn)地： 中國大陸
    訪問次數(shù)： 1660
    發(fā)布時間： 2016/3/28 15:13:38
    Anaplastic large cell lymphoma (ALCL) is usually composed of large
    pleomorphic cells which are reported to express CD30 antigen and the
    epithelial membrane antigen (EMA).
  徠卡抗體Anaplastic Lymphoma Kinase
Clone 5A4
7 mL BOND ready-to-use PA0306 P (HIER)
Antigen Background
Anaplastic large cell lymphoma (ALCL) is usually composed of large
pleomorphic cells which are reported to express CD30 antigen ａnd the
epithelial membrane antigen (EMA). These tumor cells tend to occur in
younger individuals ａnd may be associated with cutaneous ａnd extranodal
involvement. A proportion of these cases contain a chromosomal
translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
cell lymphomas account for approximately 25 percent of all non-Hodgkin＇s
lymphomas in children ａnd young adults, of which one third carries the NPMALK gene translocation.


Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
section.

更新時間：2024/9/10 12:38:20


標簽：ALCL   克隆抗體   Anaplastic   Lymphoma   Kinase   

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